The National Museum of Science and Technology (once Technics) “Leonardo da Vinci” was created on 15th February 1953. Today it is a Private law Foundation, whose institutional associates are Ministries, Public Bodies and Milan’s Universities. Next to its Chairmanship and Administration, the Museum is operationally developed by the Directorate-General. The Museum’s employees and collaborators design, develop and directly deliver day-to-day activities and extensive projects. Alongside with these internal resources there are also institutions, firms, professionals, researchers and experts, volunteers that complete the network through which the Museum achieves its mission. The Museum has achieved major significance today in important areas: an international level of excellence in the protection, conservation, and enhancement of technical-scientific collections and in museological and museographic renewal; the undisputed national leader, and one of Europe’s major leaders, in museum education for STEM fields (Science, Technology, Engineering, Mathematics) through methodological research and a very broad, high-quality offer of education and training; a major contributor in the building of collaborative projects and active dialogue with the world’s principal museums, with research institutions of Italy and abroad, and with the Italian business system; a world reference for the interpretation and the narration of the work of Leonardo da Vinci, the engineer. The Museum’s macro-objectives are: rediscovery of the result of its dedication to Leonardo da Vinci as a symbol of the union of humanistic and scientific cultures, and as a starting point for building a vision based on the meeting of branches of knowledge and their interconnections; to transmit to present generations (by interpreting and enhancing accessibility) and to future generations (by protecting assets) one of the most relevant aspects of our identity, in a perspective including both the local and global, namely, the evolution of science, technology, and industrial production, as the underlying basis of contemporary society, through safeguarding and critical interpretation of material and immaterial testimonies of history; to actively involve citizens in the construction of a scientific citizenship; to raise awareness among stakeholders on important issues; to educate new generations in STEM fields (Science, Technology, Engineering, Mathematics) making use of innovative methodologies; to develop public engagement programs to foster a direct relationship between citizens and the scientific community.